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In 1990, Dr. Rudman studied growth hormone
in men over 60 years of age and found amazing positive effects and no negative
effects. Many studies since that time have shown that replenishment of the
low levels of growth hormone can partially reverse the aging process and return
patients back to a more vigorous state of health.
growth hormone, which is secreted by the pituitary gland in the brain, is
also responsible for re-growth and healing, decreased body fat and cholesterol,
higher energy level and enhanced sexual performance. It is responsible for
the re-growth of vital organs and for restoration of a youthful immune system.
It increases strength of bones by increasing the function of osteoblasts.
It results in faster healing of wounds and also has shown tremendous improvement
in postoperative healing by stimulation of cellular repair and protein syntheses.
Replenishment results in increased energy levels, elevated mood, and increased
physical and psychological well being.
is consistent improvement in this parameter with a usual 10% increase in lean
body mass and a 5 to 10% decrease in body fat. Fat loss was greatest in the
abdominal region. The alterations in body composition are reversed. The lean
body mass increases as the adipose tissue decreases. This accounts for the fact
that there may not always be an overall weight loss because of the increased
muscle mass. In addition, human growth hormone affects the liver, kidneys, spleen,
skin and bone, and is protective against atrophy by causing re-growth of tissue.
hormone induces decomposition of adipose tissue. The adipose cell volume will
decrease significantly. Metabolism is increased which results in the degradation
of fat. In addition, cholesterol is lowered.
hormone restores abnormal low levels of extracellular fluid. This cellular dehydration
is implicated in many of the signs of aging. By replenishing this extracellular
water, skin becomes thicker and wrinkles become less noticeable. Also, there
is normalization of kidney function and improvement in sweating capacity.
growth hormone therapy, there is a definite improvement in bone density. One
study showed an increased bone mass of 2% per year.
is an increase in muscle mass, which accounts for the improved ability to exercise
with a concomitant increase in strength. There is also an increase in cardiac
output. There is an increase in maximum oxygen uptake with a concomitant improvement
in cardiac function.
recently, the supply of growth hormone was scarce because it had to be obtained
from the pituitary gland of cadavers. This hormone is now available in large
supply due to genetic engineering techniques that have been developed through
recombinant DNA technology. HGH, also known, as Somatotropin is the most abundant
hormone secreted by the pituitary gland. It produces at a rate that peaks during
adolescence when accelerated growth occurs. Daily growth hormone secretion diminishes
with age to the extent that a 60-year-old may secrete 25% of the HGH secreted
by a 20-year-old. Growth hormone is primarily released in pulses that take place
during the beginning phases of sleep, then it is quickly converted in the liver
to its powerful growth promoting metabolite, Insulin-like Growth Factor type
1 (IGF1) also known as somatomedin C. IGF1 elicits most of the effects associated
with growth hormone and is measured in the blood to determine the level of growth
Signs of growth hormone deficiency are equivalent to those
signs of aging. Body composition shifts to increase fat with a corresponding
decrease in muscle mass and decreased capacity. There is demineralization
of bone. Listed below are some of the more common changes.
- Increased cardiovascular mortality
- Abnormal body fat
- Bone density
- Impaired physical performance, muscle tone and strength
- Psychosocial deficits
- Poor sleep
- Thinning of hair, skin and muscle
growth hormone has been shown in some studies to have side effects, which include
carpal tunnel syndrome, arthritis and edema. This was experienced only when
high doses were given. Numerous studies have shown that side effects can be
avoided by slow initial administration, proper monitoring of levels and administration
on a daily basis in what is called a low-dose, high frequency method. Some researchers
have used growth hormone injections twice daily. Recent research has shown that
the majority of naturally produced HGH is pulsed from the pituitary gland at
night. This has lead to studies showing that a once a day injection at night
seems to have the most beneficial effect, as evidenced by raising the somatomedin-C
levels of protein produced by the liver. Human growth hormone cannot be measured
directly unless extremely sensitive test are used. Therefore, the somatomedin-C
(or insulin growth factor1, IGF-1) is most commonly used as an indirect measurement
of growth hormone. However, this method is, at times, widely insensitive due
to the natural daily fluctuation in hormone level. Although somatomedin-C is
frequently used to monitor HGH, it is still not an exact measurement. However,
more importantly, the somatomedin-C level is used to make sure that the amount
of growth hormone administration is not in excess, which in turn will prevent
any of the minor side effects. In summary, when the correct method of administration
is employed and the levels monitored correctly, there will be no side effects.
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